1. Aoi W, Hirano N, Lassiter DG, Björnholm M, Chibalin AV, Sakuma K, Tanimura Y, Mizushima K, Takagi T,
Naito Y, Zierath JR, Krook A. Secreted protein acidic and rich in cysteine (SPARC) improves glucose
tolerance via AMP-activated protein kinase activation. FASEB J 33: 10551-10562, 2019
2. Tabata S, Aizawa M, Kinoshita M, Ito Y, Kawamura Y, Takebe M, Pan W, Sakuma K. The influence of isoflavone
for denervation-induced muscle atrophy. Eur J Nutr 58: 291-300, 2019
3. Asami Y, Aizawa M, Kinoshita M, Ishikawa J, Sakuma K. Resveratrol attenuates denervation-induced
muscle atrophy due to the blockade of atrogin-1 and p62 accumulation. Int J Med Sci 15: 628-637, 2018
4. Sakuma K, Kinoshita M, Ito Y, Aizawa M, Aoi W, Yamaguchi A. p62/SQSTM1 but not LC3 is accumulated in
sarcopenic muscle of mice. J Cachexia Sarcopenia Muscle 7: 204-212, 2016
5. Yamaguchi A, Sakuma K, Fujikawa T, Morita I. Expression of specific IGFBPs is associated with those of the
proliferating and differentiating markers in regenerating rat plantaris muscle. J Physiol Sci 63: 71-77, 2013
6. Aoi W, Naito Y, Takagi T, Tanimura Y, Takanami Y, Kawai Y, Sakuma K, Hang LP, Mizushima K, Hirai Y, Koyama
R, Wada S, Higashi A, Kokura S, Ichikawa H, Yoshikawa T. A novel myokine, secreted protein acidic and rich in
cysteine (SPARC), suppresses colon tumorigenesis via regular exercise. Gut 62: 882-889, 2013
7. Wagatsuma A, Sakuma K. Myogenic and angiogenic pathways are sequentially activated during postnatal
muscle regeneration. Current Topics in Peptide and Protein Research 13: 49-59, 2012.
8. Sakuma K, Yamaguchi A. Cyclosporin A inhibits the growth of neonatal MHC-expressing myotubes independent
of NFATc1 and NFATc3 in the mechanically overloaded soleus muscle of mice. Am J Mol Biol 1: 7-16, 2011
9. Hokari F, Kawasaki E, Sakai A, Koshinaka K, Sakuma K, Kawanaka K. Muscle contractile activity regulates Sirt3
protein expression in rat skeletal muscles. J Appl Physiol 109: 332-340, 2010
10. Akiho M, Nakashima H, Sakata M, Yamasa Y, Yamaguchi A, Sakuma K. Expression profile of Notch-1 in
mechanically overloaded plantaris muscle of mice. Life Sci 86: 59-65, 2010
11. Sakuma K, Watanabe K, Hotta N, Koike T, Ishida K, Katayama K, Akima H. The adaptive responses in several
mediators linked with hypertrophy and atrophy of skeletal muscle after lower limb unloading in humans. Acta
Physiol (Oxf) 197: 151-159, 2009
12. Tokugawa S, Sakuma K, Fujiwara H, Hirata M, Oda R, Morisaki S, Yasuhara M, Kubo T. The expression pattern
of PKCtheta in satellite cells of normal and regenerating muscle in the rat. Neuropathology 29: 211-218, 2009
13. Sakuma K, Akiho M, Nakashima H, Akima H, Yasuhara M. Age-related reductions in expression of serum
response factor and myocardin-related transcription factor A in mouse skeletal muscles. Biochim Biophys Acta
Mol Basis Dis 1782: 453-461, 2008
14. Sakuma K, Akiho M, Nakashima H, Nakao R, Hirata M, Inashima S, Yamaguchi A, Yasuhara M. Cyclosporin A
modulates cellular localization of MEF2C protein and blocks fiber hypertrophy in the overloaded soleus muscle
of mice. Acta Neuropathol (Berl) 115: 663-674, 2008
15. Tanaka Y, Yamaguchi A, Fujikawa T, Sakuma K, Morita I, Ishii K. Expression of mRNA for specific fibroblast
growth factors associates with that of the myogenic markers MyoD and PCNA in regenerating and overloaded
rat plantaris muscle. Acta Physiol (Oxf) 194: 149-159, 2008
16. Hirata M, Sakuma K, Okajima S, Fujiwara H, Inashima S, Yasuhara M, Kubo T. Increased expression of
neuregulin-1 in differentiating muscle satellite cells and in motoneurons during muscle regeneration. Acta
Neuropathol (Berl) 113: 451-459, 2007
17. Sakuma K, Nakao R, Yamasa Y, Yasuhara M. Normal distribution of presenilin-1 and nicastrin in skeletal
muscle and the differential responses of these proteins after denervation. Biochim Biophys Acta Gen Subj
18. Yamaguchi A, Fujikawa T, Tateoka M, Soya H, Sakuma K, Sugiura T, Morita I, Ikeda Y, Hirai T. The expression
of IGF-I and myostatin mRNAs in skeletal muscle of hypophysectomized and underfed rats during postnatal
growth. Acta Physiol (Oxf) 186: 291-300, 2006
19. Nishikawa J, Sakuma K, Sorimachi Y, Yoshimoto K, Yasuhara M. Increase of cardiotrophin-1 immunoreactivity
in regenerating and overloaded but not denervated muscles of rats. Neuropathology 25: 54-65, 2005
20. Sakuma K, Nakao R, Aoi W, Inashima S, Fujikawa T, Hirata M, Sano M, Yasuhara M. Cyclosporin A treatment
upregulates Id1 and Smad3 expression and delays skeletal muscle regeneration. Acta Neuropathol (Berl) 110:
21. Fujikawa T, Tamura K, Kawase T, Mori Y, Sakai RR, Sakuma K, Yamaguchi A, Ogata M, Soya H, Nakashima K.
Prolactin knockdown in the rat paraventricular nucleus by a morpholino-antisence oligonucleotide causes
hypocalcemia and stress gastric erosion. Endocrinology 146: 3471-3480, 2005
22. Sugiura T, Abe N, Nagano M, Goto K, Sakuma K, Naito H, Yoshioka T, Powers SK. Changes in PKB/Akt and
calcineurin signaling during recovery in atrophied soleus muscle induced by unloading. Am J Physiol Regul
Integr Comp Physiol 288: 1273-1278, 2005
23. Sakuma K, Nakao R, Inashima S, Hirata M, Kubo T, Yasuhara M. Marked reduction of focal adhesion kinase,
serum response factor and myocyte enhancer factor 2C, but increase in RhoA and myostatin in the hindlimb dy
mouse muscles. Acta Neuropathol (Berl) 108: 241-249, 2004
24. Aoi W, Naito Y, Takanami Y, Kawai Y, Sakuma K, Yoshida N, Yoshikawa T. Oxidative stress and delayed-onset
muscle damage after exercise. Free Radic Biol Med 37: 480-487, 2004
25. Yoshida N, Uchiyama K, Kuroda M, Sakuma K, Kokura S, Ichikawa H, Naito Y, Takemura T, Yoshikawa T,
Okanoue T. Interleukin-8 expression in the esophageal mucosa of patients with gastroesophageal reflux
disease. Scand J Gastroenterol 39: 816-822, 2004
26. Sakuma K, Nishikawa J, Nakao R, Watanabe K, Totsuka T, Nakano H, Sano M, Yasuhara M. Calcineurin is a
potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2. Acta Neuropathol
27. Sakuma K, Nishikawa J, Nakao R, Nakano H, Sano M, Yasuhara M. Serum response factor plays an important
role in the mechanically overloaded plantaris muscle of rats. Histochem Cell Biol 119: 149-160, 2003
28. Aoi W, Naito Y, Sakuma K, Kuchide M, Tokuda H, Maoka T, Toyokuni S, Oka S, Yasuhara M, Yoshikawa T.
Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. Antioxid Redox Signal 5:
29. Sakuma K, Watanabe K, Totsuka T, Sano M, Nakano H, Nakao R, Nishikawa J, Sorimachi Y, Yoshimoto K,
Yasuhara M. The reciprocal change of neurotrophin-4 and glial cell line-derived neurotrophic factor protein in
the muscles, spinal cord and cerebellum of the dy mouse. Acta Neuropathol (Berl) 104: 482-492, 2002
30. Sakuma K, Watanabe K, Sano M, Uramoto I, Nakano H, Li Y-J, Kaneda S, Sorimachi Y, Yoshimoto K, Yasuhara
M, Totsuka T. A possible role for BDNF, NT-4 and TrkB in the spinal cord and muscle of rat subjected to
mechanical overload, bupivacaine injection and axotomy. Brain Res 907: 1-19, 2001
31. Sakuma K, Watanabe K, Sano M, Uramoto I, Totsuka T. Postnatal profiles of myogenic regulatory factors and
the receptors of TGF-beta 2, LIF and IGF-I in the gastrocnemius and rectus femoris muscles of dy mouse.
Acta Neuropathol (Berl) 99: 169-176, 2000
32. Sakuma K, Watanabe K, Sano M, Kitajima S, Sakamoto K, Uramoto I, Totsuka T. The adaptive response of
transforming growth factor-β2 and -βRII in the overloaded, regenerating and denervated muscles of rats. Acta
Neuropathol (Berl) 99: 177-185, 2000
33. Sakuma K, Watanabe K, Sano M, Sakamoto K, Uramoto I, Totsuka T. The adaptive response of MyoD protein
in the overloaded, regenerating and denervated rat muscles. Biochim Biophys Acta Gen Subj 1428: 284-292,
34. Sakuma K, Watanabe K, Totsuka T, Uramoto I, Sakamoto K, Sano M. Differential adaptations of insulin-like
growth factor, basic fibroblast growth factor and leukemia inhibitory factor in the plantaris muscle of rats by
mechanical overloading : an immunohistochemical study. Acta Neuropathol (Berl) 95: 123-130, 1998
35. Sakuma K, Watanabe K, Totsuka T, Kato K. Pathological changes in levels of three small stress proteins, αB
crystallin, HSP 27 and p20, in the hindlimb muscles of dy mouse. Biochim Biophys Acta Mol Basis Dis 1406:
36. Totsuka T, Watanabe K, Uramoto I, Sakuma K, Mizutani T. Muscular dystrophy: centronucleation may reflect a
compensatory activation of defective myonuclei. J Biomed Sci 5: 54-61, 1998
37. Sakuma K, Saitoh A, Katsuta S. Denervation-induced region-specific changes in fibre types in the soleus and
plantaris muscles of rats. Acta Neuropathol (Berl) 93: 129-35, 1997
38. Yamaguchi A, Sakuma K, Morita I, Soya H, Takeda H, Katsuta S. Changes in fibre types in rat soleus and
plantaris muscles following hypophysectomy and compensatory overload. Acta Physiol Scand 158: 89-95, 1996
39. Sakuma K, Yamaguchi A, Katsuta S. Are region-specific changes in fibre types attributable to nonuniform
muscle hypertrophy by overloading? Eur J Appl Physiol Occup Physiol 71: 499-504, 1995
40. Sakuma K, Yamaguchi A, Ohmori H, Katsuta S. Nonuniform changes in fibre types in the soleus muscle of the
developing rat. Eur J Appl Physiol Occup Physiol 70: 132-137, 1995
41. Nakano H, Hayashi K, Saitoh A, Sakuma K, Katsuta S. Oxidative enzyme activity in the rat soleus muscle and
its motoneurons during postnatal maturation. Brain Res Bull 38: 235-238, 1995
42. 佐久間邦弘, 山口明彦, 勝田茂. 発育期のラットにおけるヒラメ筋および長指伸筋の酵素活性に及ぼす低栄養の
影響. 体力科学 42: 155-163, 1993